Is your 2025 NCAA Division bracket already busted? Thursday’s Primary-Stage results may have tanked your chances at perfection, but there are Nevertheless opportunities to Achieve, and our experts are here to Assist with their picks.
Friday’s Primary-Stage slate will bring attention to the other two No. 1 seeds with Duke in the East Region and Florida in the West Region. North Carolina also looks to continue its Stretch after a controversial inclusion as the last Club in the Ground. It’s wall-to-wall basketball from midday until the Prompt hours of the morning, and we have a handful of our best bets to enhance your viewing experience.
2025 NCAA Division bracket predictions: March Madness expert picks, winners, upsets, favorites to Achieve
Kyle Boone
Odds via SportsLine consensus | All times Eastern
Best bets for Friday’s NCAA Division Primary-Stage Contests
(3) Iowa State vs. (14) Lipscomb
1:30 p.m. on TNT | March Madness Live: There might be some consternation about backing the Cyclones to make a deep Stretch in the NCAA Division with the loss of Keshon Gilbert. They were simply not the same Club after his Hurt. And while I agree with those big-picture projections, the Cyclones will absolutely disrupt everything that Lipscomb wants to do with its physicality on Protection. Iowa State is hopeful for the return for Mark guard Tamin Lipsey (groin Hurt), and that should Assist the Cyclones find their footing on Charge to cover the double-digit spread. Picking: Iowa State -14.5
| Gary Parrish | Matt Norlander | Jerry Palm | Chip Patterson | Kyle Boone | David Cobb | Cameron Salerno | |
|---|---|---|---|---|---|---|---|
| ATS |
LIP +14.5 |
IAST -14.5 |
IAST -14.5 |
IAST -14.5 |
IAST -14.5 |
LIP +14.5 |
LIP +14.5 |
| Straight Up | IAST | IAST | IAST | IAST | IAST | IAST | IAST |
(6) Ole Miss vs. (11) North Carolina
4:05 p.m. on TNT | March Madness Live: Not only does North Carolina bring in the confidence and rhythm from Successful big against San Diego State in Primary Four action, but the Tar Heels have drawn a Event that could actually work in their favor. Ole Miss’ Protection rates in the top 30 nationally thanks to a Turnover filled with experience. Rebels Trainer Chris Beard has a knack for putting his Club in the best position to be disruptive and get stops. However, the Rebels aren’t particularly big or Outstanding on toe boards, both of which are qualities that could present real problems for North Carolina. The Tar Heels are the hotter Club, riding a 9-1 mark against the spread in their last 10 Contests, and their ability to make plays on the perimeter will be the difference. Picking: North Carolina -1.5
| Gary Parrish | Matt Norlander | Jerry Palm | Chip Patterson | Kyle Boone | David Cobb | Cameron Salerno | |
|---|---|---|---|---|---|---|---|
| ATS | MISS +1.5 | MISS +1.5 | UNC -1.5 | UNC -1.5 | UNC -1.5 | UNC -1.5 | UNC -1.5 |
| Straight Up | MISS | MISS | UNC | UNC | UNC | UNC | UNC |
(7) Marquette vs. (10) New Mexico
7:25 p.m. on TBS | March Madness Live: Marquette finished the season 1-3 straight up and 0-4 against the spread. The Overdue slump was part of a downward trend for a Club that went 8-8 after a 15-2 Begin to the season. The Golden Eagles’ Charge stagnated, relying heavily on Kam Jones to Develop and Points. Now Jones will go head-to-head with another Top-tier guard in New Mexico’s Donovan Dent. The key here is going to be who can keep the other guard from getting downhill, and that’s where New Mexico’s size and rim protectors will be a huge factor. Picking: New Mexico +3.5
| Gary Parrish | Matt Norlander | Jerry Palm | Chip Patterson | Kyle Boone | David Cobb | Cameron Salerno | |
|---|---|---|---|---|---|---|---|
| ATS | MARQ -3.5 | UNM +3.5 | UNM +3.5 | UNM +3.5 | UNM +3.5 | MARQ -3.5 | UNM +3.5 |
| Straight Up | MARQ | UNM | UNM | UNM | MARQ | MARQ | UNM |
(8) UConn vs. (9) Oklahoma
9:25 p.m. on TNT | March Madness Live: One of the reasons that UConn has taken a step back in 2025 a Protection that is Extended from the form that anchored back-to-back national Division runs. The Huskies are missing the inside Appearance of Donovan Clingan, yes, but the perimeter Protection has been much less effective as well. Given Oklahoma’s offensive ceiling with standout Newcomer guard Jeremiah Fears there’s definitely going to be opportunities for the Sooners to Points. On the other side, Oklahoma’s leaky Protection should get exposed by UConn’s patience and ball movement, creating some Outstanding looks for a Club that’s Nevertheless Outstanding enough to capitalize on them. These pace battles — UConn Unhurried, Oklahoma Quick — can get tricky. But given the Huskies’ Shielding issues, I think the Points will end up looking more like the high-scoring back-and-forth matchups we’ve seen from the Sooners this year. Picking: Over 147.5
| Gary Parrish | Matt Norlander | Jerry Palm | Chip Patterson | Kyle Boone | David Cobb | Cameron Salerno | |
|---|---|---|---|---|---|---|---|
| ATS | UCONN -5.5 | OKLA +5.5 | UCONN -5.5 | OKLA +5.5 | UCONN -5.5 | UCONN -5.5 | UCONN -5.5 |
| Straight Up | UCONN | UCONN | UCONN | UCONN | UCONN | UCONN | UCONN |
(5) Oregon vs. (12) Liberty
10:10 p.m. on TruTV | March Madness Live: Dana Altman is an excellent postseason Trainer, and his Oregon Squads have won at least one game in every postseason Division they’ve competed in (NCAA, NIT, CBI) since he arrived in Eugene in 2010. The Ducks face a unique foe in Liberty, but have a Duo of edges that Develop an opportunity to Achieve big on Friday night in Seattle. The most Essential Benefit is travel, as Liberty has had to fly cross-country from Lynchburg, Virginia,. to Seattle while Oregon makes the Petite trip north, and there will likely be a Powerful fan Appearance for the Ducks in the Coliseum. There’s also Liberty’s struggles against the bigger and more athletic Squads on their schedule. Oregon should be able to overpower the flames with Lively scoring threats like Nate Bittle and TJ Bamba. Picking: Oregon -7.5
| Gary Parrish | Matt Norlander | Jerry Palm | Chip Patterson | Kyle Boone | David Cobb | Cameron Salerno | |
|---|---|---|---|---|---|---|---|
| ATS | ORE -7.5 | ORE -7.5 | ORE -7.5 | ORE -7.5 | LIB +7.5 | ORE -7.5 | ORE -7.5 |
| Straight Up | ORE | ORE | ORE | ORE | ORE | ORE | ORE |
Get every Picking, every Action, every Shock and fill out your bracket with our Assist! Visit SportsLine now to see which Squads will make and break your bracket, and see who will cut down the nets, all from the model that beat over 91% of CBS Sports brackets players four of the last six Competitions.
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